WHO grants prequalification to R21/Matrix-M — the second malaria vaccine to achieve global procurement status
The World Health Organization awarded prequalification status to R21/Matrix-M on December 21, 2023 — making it only the second malaria vaccine in history to achieve this standing, alongside Gates-funded RTS,S. WHO prequalification enabled Gavi, UNICEF, and national health ministries to procure the vaccine at scale through multilateral channels. With two prequalified malaria vaccines now available for the first time, the global malaria community gained enough combined production capacity to begin immunising tens of millions of African children annually — a crucial threshold for achieving meaningful population-level protection.
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R21/Matrix-M malaria vaccine receives first national regulatory approval — in Ghana
Related Accomplishments
January 2026
Gates-backed World Mosquito Program reaches 16 million people protected from dengue via Wolbachia method
The World Mosquito Program — backed in part by the Gates Foundation — announced in January 2026 that its Wolbachia-infected mosquito releases had reached over 16.1 million people across multiple countries, including Colombia, Indonesia, Brazil, Sri Lanka, Fiji, Vanuatu, and Vietnam. Wolbachia-carrying Aedes aegypti mosquitoes — which block dengue, Zika, chikungunya, and yellow fever transmission — had established self-sustaining populations in treated cities without requiring ongoing releases. Gold-standard randomised trials in Indonesia showed a 77% reduction in dengue incidence. The program represented one of the largest and most cost-effective vector control deployments in history.
December 2025
Gates Foundation Pledges $100 Million to Global Financing Facility for Women's and Children's Health 2026–2030
On December 6, 2025, at the Universal Health Coverage High-Level Forum in Tokyo, the Gates Foundation pledged $100 million to the World Bank-hosted Global Financing Facility's 2026–2030 strategy for ending preventable deaths among women, children, and adolescents in LMICs. The pledge brings the foundation's total GFF commitment past $500 million since 2015. The GFF provides catalytic grant financing and technical assistance to strengthen LMIC health systems and expand quality access to health and nutrition services for the world's most vulnerable populations.
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