R21/Matrix-M malaria vaccine receives first national regulatory approval — in Ghana
Ghana's Food and Drugs Authority became the first national regulator in the world to grant full licensure to the R21/Matrix-M malaria vaccine — developed by the University of Oxford with Gates Foundation funding, and manufactured by the Serum Institute of India. With 75–77% efficacy in trials — higher than RTS,S — R21 met the WHO's own target for malaria vaccine performance. The Serum Institute aimed to produce up to 200 million doses annually, dramatically exceeding the manufacturing capacity available for RTS,S, positioning R21 as the higher-volume vaccine for sub-Saharan Africa's mass vaccination programmes.
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Related Accomplishments
January 2026
Gates-backed World Mosquito Program reaches 16 million people protected from dengue via Wolbachia method
The World Mosquito Program — backed in part by the Gates Foundation — announced in January 2026 that its Wolbachia-infected mosquito releases had reached over 16.1 million people across multiple countries, including Colombia, Indonesia, Brazil, Sri Lanka, Fiji, Vanuatu, and Vietnam. Wolbachia-carrying Aedes aegypti mosquitoes — which block dengue, Zika, chikungunya, and yellow fever transmission — had established self-sustaining populations in treated cities without requiring ongoing releases. Gold-standard randomised trials in Indonesia showed a 77% reduction in dengue incidence. The program represented one of the largest and most cost-effective vector control deployments in history.
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Gates Foundation Pledges $100 Million to Global Financing Facility for Women's and Children's Health 2026–2030
On December 6, 2025, at the Universal Health Coverage High-Level Forum in Tokyo, the Gates Foundation pledged $100 million to the World Bank-hosted Global Financing Facility's 2026–2030 strategy for ending preventable deaths among women, children, and adolescents in LMICs. The pledge brings the foundation's total GFF commitment past $500 million since 2015. The GFF provides catalytic grant financing and technical assistance to strengthen LMIC health systems and expand quality access to health and nutrition services for the world's most vulnerable populations.
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