CEPI Funded Nipah Virus Vaccine Candidate Enters First Human Phase 1 Trial
CEPI — co-founded at Davos 2017 with a $100 million Gates Foundation contribution — awarded up to $25 million to develop HeV-sG-V, a recombinant subunit Nipah virus vaccine. In March 2020, HeV-sG-V became the first Nipah vaccine to enter Phase 1 human trials, enrolling 192 adults at Cincinnati Children's Hospital. Results confirmed dose-dependent immune responses with no serious adverse events, establishing immunogenicity proof for potential reactive deployment against a pathogen with up to 75 percent case fatality rate in humans.
Source: https://cepi.net/cepi-funded-nipah-virus-vaccine-candidate-first-reach-phase-1-clinical-trial
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January 2026
Gates-backed World Mosquito Program reaches 16 million people protected from dengue via Wolbachia method
The World Mosquito Program — backed in part by the Gates Foundation — announced in January 2026 that its Wolbachia-infected mosquito releases had reached over 16.1 million people across multiple countries, including Colombia, Indonesia, Brazil, Sri Lanka, Fiji, Vanuatu, and Vietnam. Wolbachia-carrying Aedes aegypti mosquitoes — which block dengue, Zika, chikungunya, and yellow fever transmission — had established self-sustaining populations in treated cities without requiring ongoing releases. Gold-standard randomised trials in Indonesia showed a 77% reduction in dengue incidence. The program represented one of the largest and most cost-effective vector control deployments in history.
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